Beating Poisson encapsulation statistics using close-packed ordering

被引：149

作者：

Abate, Adam R. ^{[1
]}

Chen, Chia-Hung ^{[2
]}

Agresti, Jeremy J. ^{[1
]}

Weitz, David A. ^{[1
]}

机构：

[1] Harvard Univ, Dept Phys, Sch Engn & Appl Sci, Cambridge, MA 02138 USA

[2] Univ Cambridge, Cavendish Lab, Cambridge CB3 0HE, England

来源：

LAB ON A CHIP | 2009年 / 9卷 / 18期

基金：

美国国家科学基金会;

关键词：

ON-A-CHIP; SINGLE-CELLS; MICROFLUIDIC DEVICE; DROPLET MICROFLUIDICS;

D O I：

10.1039/b909386a

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Loading drops with discrete objects, such as particles and cells, is often necessary when performing chemical and biological assays in microfluidic devices. However, random loading techniques are inefficient, yielding a majority of empty and unusable drops. We use deformable particles that are close packed to insert a controllable number of particles into every drop. This provides a simple, flexible means of efficiently encapsulating a controllable number of particles per drop.

引用

页码：2628 / 2631

页数：4

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