Regioselective Ruthenium-Catalyzed Direct Benzylations of Arenes through C-H Bond Cleavages

被引：130

作者：

Ackermann, Lutz ^{[1
]}

Novak, Petr ^{[1
]}

机构：

[1] Univ Gottingen, Inst Organ & Biomol Chem, D-37077 Gottingen, Germany

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 21期

关键词：

CROSS-COUPLING REACTIONS; DIRECT ARYLATIONS; DIHYDROFOLATE-REDUCTASE; PHOSPHINE OXIDES; ARYL CHLORIDES; PALLADIUM; FUNCTIONALIZATION; ACTIVATION; HALIDES; INHIBITORS;

D O I：

10.1021/ol902115f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Highly regioselective ruthenium-catalyzed direct benzylations through C-H bond cleavages were accomplished under remarkably mild, nonacidic reaction conditions, for which experimental studies suggested a SEAr-type mechanism not to be operative.

引用

页码：4966 / 4969

页数：4

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