Cellular dynamics of tRNAs and their genes

被引：65

作者：

Hopper, Anita K. ^{[1
]}

Pai, Dave A. ^{[2
]}

Engelke, David R. ^{[2
]}

机构：

[1] Ohio State Univ, Dept Mol Genet, Ctr RNA Biol, Columbus, OH 43210 USA

[2] Univ Michigan, Dept Biol Chem, Ann Arbor, MI 48109 USA

来源：

FEBS LETTERS | 2010年 / 584卷 / 02期

关键词：

tRNA transcription; tRNA processing; tRNA modification; Nucleolus; tRNA nuclear export; tRNA retrograde movement; tRNA turnover; YEAST TRANSFER-RNA; CYTOPLASMIC TRANSFER-RNA; NUCLEAR EXPORT RECEPTOR; SACCHAROMYCES-CEREVISIAE; POLYMERASE-III; QUALITY-CONTROL; NUCLEOCYTOPLASMIC TRANSPORT; SPLICING ENDONUCLEASE; INITIATOR TRNA(MET); OXIDATIVE STRESS;

D O I：

10.1016/j.febslet.2009.11.053

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This discussion focuses on the cellular dynamics of tRNA transcription, processing, and turnover. Early tRNA biosynthesis steps are shared among most tRNAs, while later ones are often individualized for specific tRNAs. In yeast, tRNA transcription and early processing occur coordinately in the nucleolus, requiring topological arrangement of similar to 300 tRNA genes and early processing enzymes to this site; later processing events occur in the nucleoplasm or cytoplasm. tRNA nuclear export requires multiple exporters which function in parallel and the export process is coupled with other cellular events. Nuclear-cytoplasmic tRNA subcellular movement is not unidirectional as a retrograde pathway delivers mature cytoplasmic tRNAs to the nucleus. Despite the long half-lives, there are multiple pathways to turnover damaged tRNAs or normal tRNAs upon cellular stress. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：310 / 317

页数：8

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