The chromatoid body: a germ-cell-specific RNA-processing centre

被引：238

作者：

Kotaja, Noora

Sassone-Corsi, Paolo

机构：

[1] Univ Turku, Inst Biomed, Dept Physiol, Turku 20520, Finland

[2] Univ Calif Irvine, Sch Med, Dept Pharmacol, Irvine, CA 92697 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2007年 / 8卷 / 01期

关键词：

D O I：

10.1038/nrm2081

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The chromatoid body, a unique cloud-like structure of male germ cells, moves dynamically in the cytoplasm of haploid spermatids, but its function has remained elusive for decades. Recent findings indicate that microRNA and RNA-decay pathways converge to the chromatoid body. This highly specialized structure might function as an intracellular focal domain that organizes and controls RNA processing in male germ cells.

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页码：85 / 90

页数：6

相关论文

共 73 条

[61] Mouse RanBPM is a partner gene to a germline specific RNA helicase, mouse vasa homolog protein [J].

Shibata, N ;

Tsunekawa, N ;

Okamoto-Ito, S ;

Akasu, R ;

Tokumasu, A ;

Noce, T .

MOLECULAR REPRODUCTION AND DEVELOPMENT, 2004, 67 (01) :1-7

[62] INCORPORATION OF [URIDINE-H-3] BY CHROMATOID BODY DURING RAT SPERMATOGENESIS [J].

SODERSTROM, KO ;

PARVINEN, M .

JOURNAL OF CELL BIOLOGY, 1976, 70 (01) :239-246

[63] Assembly and function of RNA silencing complexes [J].

Sontheimer, EJ .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2005, 6 (02) :127-138

[64]

Styhler S, 1998, DEVELOPMENT, V125, P1569

[65]

Tanaka SS, 2000, GENE DEV, V14, P841

[66] Processing bodies require RNA for assembly and contain nontranslating mRNAs [J].

Teixeira, D ;

Sheth, U ;

Valencia-Sanchez, MA ;

Brengues, M ;

Parker, R .

RNA, 2005, 11 (04) :371-382

[67] Expression and intracellular localization of mouse Vasa-homologue protein during germ cell development [J].

Toyooka, Y ;

Tsunekawa, N ;

Takahashi, Y ;

Matsui, Y ;

Satoh, M ;

Noce, T .

MECHANISMS OF DEVELOPMENT, 2000, 93 (1-2) :139-149

[68] Gonadotropin-regulated testicular RNA helicase (GRTH/Ddx25) is essential for spermatid development and completion of spermatogenesis [J].

Tsai-Morris, CH ;

Sheng, Y ;

Lee, E ;

Lei, KJ ;

Dufau, ML .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (17) :6373-6378

[69] Intercellular organelle traffic through cytoplasmic bridges in early spermatids of the rat:: Mechanisms of haploid gene product sharing [J].

Ventelä, S ;

Toppari, J ;

Parvinen, M .

MOLECULAR BIOLOGY OF THE CELL, 2003, 14 (07) :2768-2780

[70]

WALT H, 1984, CELL TISSUE RES, V236, P487, DOI 10.1007/BF00214254

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