2-Aryl propionamides via 1,4-aryl radical migration from N-arylsulfonyl-2-bromopropionamides

被引：23

作者：

Clark, Andrew J. ^{[1
]}

Coles, Stuart R. ^{[1
]}

Collis, Alana ^{[1
]}

Fullaway, David R. ^{[1
]}

Murphy, Nicholas P. ^{[1
]}

Wilson, Paul ^{[1
]}

机构：

[1] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 46期

基金：

英国工程与自然科学研究理事会;

关键词：

Copper; ATRC; Atom transfer; Radical; Aryl migration; Dimethylpiperazine; COPPER-CATALYZED CYCLIZATION; N-ALLYLTRICHLOROACETAMIDES; GAMMA-LACTAMS; BIARYLS;

D O I：

10.1016/j.tetlet.2009.08.125

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reaction of N-alkyl-N-arylsulfonyl-2-halo-propionamides with pentamethyldiethylenetriamine and either CuBr or CuCl leads to 2-aryl propionamides via initial radical generation, 1,4-aryl migration with loss of SO2 and reduction of the intermediate amidyl radical in 40-99% yields. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：6311 / 6314

页数：4

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