Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity

被引：1353

作者：

Zhernakova, Alexandra ^{[1
,2
]}

Kurilshikov, Alexander ^{[3
,4
]}

Bonder, Marc Jan ^{[1
]}

Tigchelaar, Ettje F. ^{[1
,2
]}

Schirmer, Melanie ^{[5
,6
]}

Vatanen, Tommi ^{[5
,7
]}

Mujagic, Zlatan ^{[2
,8
]}

Vila, Arnau Vich ^{[9
]}

Falony, Gwen ^{[10
,11
]}

Vieira-Silva, Sara ^{[10
,11
]}

Wang, Jun ^{[10
,11
]}

Imhann, Floris ^{[9
]}

Brandsma, Eelke ^{[12
]}

Jankipersadsing, Soesma A. ^{[1
]}

Joossens, Marie ^{[10
,11
,13
]}

Cenit, Maria Carmen ^{[1
,14
,15
]}

Deelen, Patrick ^{[1
,16
]}

Swertz, Morris A. ^{[1
,16
]}

Weersma, Rinse K. ^{[9
]}

Feskens, Edith J. M. ^{[2
,17
]}

Netea, Mihai G. ^{[18
,19
]}

Gevers, Dirk ^{[5
]}

Jonkers, Daisy ^{[8
]}

Franke, Lude ^{[1
]}

Aulchenko, Yurii S. ^{[4
,20
,21
,22
]}

Huttenhower, Curtis ^{[5
,6
]}

Raes, Jeroen ^{[10
,11
,13
]}

Hofker, Marten H. ^{[12
]}

Xavier, Ramnik J. ^{[5
,23
,24
,25
,26
]}

Wijmenga, Cisca ^{[1
]}

Fu, Jingyuan ^{[1
,12
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands

[2] Top Inst Food & Nutr, Wageningen, Netherlands

[3] Inst Chem Biol & Fundamental Med SB RAS, Novosibirsk, Russia

[4] Novosibirsk State Univ, Novosibirsk 630090, Russia

[5] Broad Inst MIT & Harvard, Cambridge, MA USA

[6] Harvard Univ, TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA

[7] Aalto Univ, Sch Sci, Dept Comp Sci, Espoo, Finland

[8] Maastricht Univ, Med Ctr, NUTRIM Sch Nutr & Translat Res Metab, Div Gastroenterol Hepatol,Dept Internal Med, NL-6200 MD Maastricht, Netherlands

[9] Univ Groningen, Univ Med Ctr Groningen, Dept Gastroenterol & Hepatol, Groningen, Netherlands

[10] KU Leuven Univ Leuven, Dept Microbiol & Immunol, Rega Inst Med Res, Lab Mol Bacteriol, Leuven, Belgium

[11] VIB, Ctr Biol Dis, Leuven, Belgium

[12] Univ Groningen, Univ Med Ctr Groningen, Dept Pediat, Groningen, Netherlands

[13] Vrije Univ Brussel, Fac Sci & Bioengn Sci, Microbiol Unit, Brussels, Belgium

[14] Natl Res Council IATA CSIC, Inst Agrochem & Food Technol, Microbial Ecol Nutr & Hlth Res Grp, Valencia, Spain

[15] Dr Peset Univ Hosp, Dept Pediat, Valencia, Spain

[16] Univ Groningen, Univ Med Ctr Groningen, Genom Coordinat Ctr, Groningen, Netherlands

[17] Wageningen Univ, Div Human Nutr, NL-6700 AP Wageningen, Netherlands

[18] Radboud Univ Nijmegen, Med Ctr, Dept Internal Med, NL-6525 ED Nijmegen, Netherlands

[19] Radboud Univ Nijmegen, Med Ctr, Radboud Ctr Infect Dis, NL-6525 ED Nijmegen, Netherlands

[20] Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Ctr Global Hlth Res, Teviot Pl, Edinburgh EH8 9AG, Midlothian, Scotland

[21] PolyOmica, Groningen, Netherlands

[22] Inst Cytol & Genet SB RAS, Novosibirsk, Russia

[23] Massachusetts Gen Hosp, Ctr Computat & Integrat Biol, Boston, MA 02114 USA

[24] Massachusetts Gen Hosp, Gastrointestinal Unit, Boston, MA 02114 USA

[25] Massachusetts Gen Hosp, Ctr Study Inflammatory Bowel Dis, Boston, MA 02114 USA

[26] MIT, Ctr Microbiome Informat & Therapeut, 77 Massachusetts Ave, Cambridge, MA 02139 USA

来源：

SCIENCE | 2016年 / 352卷 / 6285期

基金：

欧洲研究理事会;

关键词：

CHROMOGRANIN-A; ENTEROTYPES; POLYPHENOLS; METABOLISM; CHILDREN;

D O I：

10.1126/science.aad3369

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Deep sequencing of the gut microbiomes of 1135 participants from a Dutch population-based cohort shows relations between the microbiome and 126 exogenous and intrinsic host factors, including 31 intrinsic factors, 12 diseases, 19 drug groups, 4 smoking categories, and 60 dietary factors. These factors collectively explain 18.7% of the variation seen in the interindividual distance of microbial composition. We could associate 110 factors to 125 species and observed that fecal chromogranin A (CgA), a protein secreted by enteroendocrine cells, was exclusively associated with 61 microbial species whose abundance collectively accounted for 53% of microbial composition. Low CgA concentrations were seen in individuals with a more diverse microbiome. These results are an important step toward a better understanding of environment-diet-microbe-host interactions.

引用

页码：565 / 569

页数：5

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