Chemical and anti-platelet constituents from Formosan Zanthoxylum simulans

被引：94

作者：

Yang, YP

Cheng, MJ

Teng, CM

Chang, YL

Tsai, IL

Chen, IS ^{[1
]}

机构：

[1] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung, Taiwan

[2] Natl Taiwan Univ, Coll Med, Inst Pharmacol, Taipei, Taiwan

来源：

PHYTOCHEMISTRY | 2002年 / 61卷 / 05期

关键词：

Zanihoxylum simulans; Rutaceae; stem wood; alkaloids; pyrrolezanthine; lignans; (-)-simulanol; gamma-pyrone; Zanthopyranone; antiplatelet aggregation activity;

D O I：

10.1016/S0031-9422(02)00268-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A pyrrole alkaloid, pyrrolezanthine [5-hydroxymethyl-1-[2-(4-hydroxyphenyl)-ethyl]-1H-pyrrole-2-carbaldehyde]; a lignan, (-)-simulanol [4- [3-hydroxymethyl-5-((E)-3-hydroxypropenyl)-7-methoxy-2,3-dihydrobenzofuran-2-yl]-2,6-dimethoxy-phenol] and a monocyclic gamma-pyrone, zanthopyranone [3,5-dimethoxy-2-methyl-pyran-4-one], together with 28 known compounds were isolated from the stem wood of Formosan Zanthoxylum simulans. Their structures were determined through spectral analyses. Among the isolates, 11 compounds showed anti-platelet aggregation activity in vitro. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：567 / 572

页数：6

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