Current approaches for deciphering the molecular basis of combined anterior pituitary hormone deficiency in humans

被引：8

作者：

Amselem, S ^{[1
]}

机构：

[1] Hop Henri Mondor, INSERM, Unite 468, F-94010 Creteil, France

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2002年 / 197卷 / 1-2期

关键词：

combined pituitary hormone deficiency; pituitary; genetics; transcription factors; mutations; development;

D O I：

10.1016/S0303-7207(02)00278-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

This review focuses on the general strategies currently used to decipher the molecular bases of combined pituitary hormone deficiency (CPHD) of genetic origin, By summarizing illustrative approaches that turned out to be successful for identifying an increasing number of genes involved in CPHD in the human, this article consider predictable obstacles specific to the investigation of these rare and heterogeneous conditions, while underlining the previously unsuspected roles of several of these genes during the development of extrapituitary structures. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：47 / 56

页数：10

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