Estrogen-related receptors: novel potential regulators of osteoarthritis pathogenesis

被引：54

作者：

Tang, Jinshuo ^{[1
]}

Liu, Tong ^{[1
]}

Wen, Xinggui ^{[2
]}

Zhou, Zhongsheng ^{[1
]}

Yan, Jingtong ^{[1
]}

Gao, Jianpeng ^{[1
]}

Zuo, Jianlin ^{[1
]}

机构：

[1] Jilin Univ, Dept Orthopead, China Japan Union Hosp, Changchun 130033, Jilin, Peoples R China

[2] Jilin Univ, Dept Hand Surg, China Japan Union Hosp, Changchun 130033, Jilin, Peoples R China

来源：

MOLECULAR MEDICINE | 2021年 / 27卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Estrogen-related receptors; ERRs; Pathogenesis; Osteoarthritis; PHOSPHORYLATION-DEPENDENT SUMOYLATION; CLEAR-CELL ADENOCARCINOMA; BROWN ADIPOSE-TISSUE; ERR-ALPHA; INVERSE AGONIST; BREAST-CANCER; IN-VITRO; ARTICULAR-CARTILAGE; KNEE ARTHROPLASTY; NUCLEAR RECEPTORS;

D O I：

10.1186/s10020-021-00270-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Osteoarthritis (OA) is a chronic inflammatory disease that is associated with articular cartilage destruction, subchondral bone alterations, synovitis, and even joint deformity and the loss of joint function. Although current basic research on the pathogenesis of OA has made remarkable progress, our understanding of this disease still needs to be further improved. Recent studies have shown that the estrogen-related receptor (ERR) family members ERR alpha and ERR gamma may play significant roles in the pathogenesis of OA. In this review, we refer to the latest research on ERRs and the pathogenesis of OA, elucidate the structure and physiopathological functions of the ERR orphan nuclear receptor family, and systematically examine the relationship between ERRs and OA at the molecular level. Moreover, we also discuss and predict the capacity of ERRs as potential targets in the clinical treatment of OA.

引用

页数：12

共 151 条

[91]

ERRα Is a Marker of Tamoxifen Response and Survival in Triple-Negative Breast Cancer [J].