Microbial transformation of (+)-androsta-1,4-diene-3,17-dione by Cephalosporium aphidicola

被引：30

作者：

Choudhary, MI ^{[1
]}

Musharraf, SG ^{[1
]}

Shaheen, F ^{[1
]}

Atta-Ur-Rahman ^{[1
]}

机构：

[1] Univ Karachi, Int Ctr Chem Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan

来源：

NATURAL PRODUCT LETTERS | 2002年 / 16卷 / 06期

关键词：

fermentation; (+)-androsta-1,4-diene-3,17-dione; androst-4-ene-3,17-dione; 17 beta-hydroxyandrosta-1,4-diene-3-one; 11 alpha-hydroxyandrosta-1,4-diene-3,17-dione; 11 alpha-hydroxyandrost-4-ene-3,17-dione; 11; alpha; 17; beta-dihydroxyandrost-4-ene-3-one; 11 alpha,17 beta-dihydroxyandrosta-1,4-diene-3-one; Cephalosporium aphidicola; Fusarium lini;

D O I：

10.1080/10575630290033132

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fermentation of (+)-androsta-1,4-diene-3,17-dione (1) with Cephalosporium aphidicola for 8 days yielded oxidative and reductive metabolites, androst-4-ene-3,17-dione (2), 17beta-hydroxyandrosta-1,4-diene-3-one (3), 11alpha-hydroxyandrosta-1,4-diene-3,17-dione (4), 11alpha-hydroxyandrost-4-ene-3,17-dione (5), 11alpha,17beta-dihydroxyandrost-4-ene-3-one (6) and 11alpha,17beta-dihydroxyandrosta-1,4-diene-3-one (7). The fermentation of 1 with Fusarium lini also yielded metabolites 3-7. The structures of these metabolites were elucidated on the basis of spectroscopic techniques.

引用

页码：377 / 382

页数：6

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