Improved perfusion-weighted MRI by a novel double inversion with proximal labeling of both tagged and control acquisitions

被引：34

作者：

Jahng, GH ^{[1
]}

Zhu, XP ^{[1
]}

Matson, GB ^{[1
]}

Weiner, MW ^{[1
]}

Schuff, N ^{[1
]}

机构：

[1] Univ Calif San Francisco, VA Med Ctr, MR Unit, San Francisco, CA 94121 USA

来源：

MAGNETIC RESONANCE IN MEDICINE | 2003年 / 49卷 / 02期

关键词：

PASL; double inversion; MT compensation; texture analyses; cerebral blood flow;

D O I：

10.1002/mrm.10339

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

A novel pulsed arterial spin labeling (PASL) technique for multislice perfusion-weighted imaging is proposed that compensates for magnetization transfer (MT) effects without sacrificing tag efficiency, and balances transient magnetic field effects (eddy currents) induced by pulsed field gradients. Improved compensation for MT is demonstrated using a phantom. Improvement in perfusion measurement was compared to other PASL techniques by acquiring perfusion images from 13 healthy volunteers (nine women and four men; age range 29-64 years; mean age 45 +/- 14 years) and second-order image texture analysis. The main improvements with the new method were significantly higher image contrast, higher mean signal intensity, and better signal uniformity across slices. In conclusion, this new PASL method should provide improved accuracy in measuring brain perfusion. (C) 2003 Wiley-Liss, Inc.

引用

页码：307 / 314

页数：8

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