Integrated optical systems for excitation delivery and broadband detection in micro-fluidic electrochromatography

被引：4

作者：

Kemme, SA ^{[1
]}

Warren, ME ^{[1
]}

Sweatt, WC ^{[1
]}

Wendt, JR ^{[1
]}

Bailey, CG ^{[1
]}

Matzke, CM ^{[1
]}

Allerman, AA ^{[1
]}

Arnold, DW ^{[1
]}

Carter, TR ^{[1
]}

Asbill, RE ^{[1
]}

Samora, S ^{[1
]}

机构：

[1] Sandia Natl Labs, Albuquerque, NM 87185 USA

来源：

OPTOELECTRONIC INTERCONNECTS VII; PHOTONICS PACKAGING AND INTEGRATION II | 2000年 / 3952卷

关键词：

D O I：

10.1117/12.384415

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

We have designed and assembled two generations of integrated micro-optical systems that deliver pump light and detect broadband laser-induced fluorescence in micro-fluidic chemical separation systems employing electrochromatography. The goal is to maintain the sensitivity attainable with larger, tabletop machines while decreasing package size and increasing throughput (by decreasing the required chemical volume). One type of micro-optical system uses vertical-cavity surface emitting lasers (VCSELs) as the excitation source. Light from the VCSELs is relayed with four-level surface relief diffractive optical elements (DOEs) and delivered to the chemical volume through substrate-mode propagation. Indirect fluorescence from dye-quenched chemical species is collected and collimated with a high numerical aperture DOE. A filter blocks the excitation wavelength, and the resulting signal is detected as the chemical separation proceeds. Variations of this original design include changing the combination of reflective and transmissive DOEs and optimizing the high numerical aperture DOE with a rotationally symmetric iterative discrete on-axis algorithm. We will discuss the results of these implemented optimizations.

引用

页码：375 / 383

页数：3

共 12 条

[1]

BAILEY CB, UNPUB ANAL CHEM

[2] OPTIMIZATION BY SIMULATED ANNEALING [J].