Five new discodermolide analogues from the marine sponge Discodermia species

被引：52

作者：

Gunasekera, SP ^{[1
]}

Paul, GK ^{[1
]}

Longley, RE ^{[1
]}

Isbrucker, RA ^{[1
]}

Pomponi, SA ^{[1
]}

机构：

[1] Harbor Branch Oceanog Inst Inc, Div Biomed Marine Res, Ft Pierce, FL 34946 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2002年 / 65卷 / 11期

关键词：

D O I：

10.1021/np020219m

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Discodermolide (1) and five new discodermolide analogues trivially named 2-epi-discodermolide (2), 2-desmethyldiscodermolide (3), 5-hydroxymethyldiscodermolate (4), 19-des-aminocarbonyldiscodermolide (5), and 9(13)-cyclodiscodermolide (6) have been isolated from marine sponges belonging to the genus Discodermia collected from the Caribbean Sea. The isolation, structure elucidation, and biological activities of 2-6 are described. The natural analogues, which were isolated in trace amounts, exhibited significant variation of cytotoxicity against the cultured murine P-388 leukemia and A-549 human adenocarcinoma cells and suggested the importance of the C-7 through C-17 moiety for potency against cultured tumor cell lines.

引用

页码：1643 / 1648

页数：6

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