Endolysosomal proteases and their inhibitors in immunity

被引：102

作者：

Bird, Phillip I. ^{[1
]}

Trapani, Joseph A. ^{[2
]}

Villadangos, Jose A. ^{[3
]}

机构：

[1] Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic 3800, Australia

[2] Peter MacCallum Canc Ctr, Canc Immunol Program, Melbourne, Vic 3002, Australia

[3] Walter & Eliza Hall Inst Med Res, Div Immunol, Parkville, Vic 3050, Australia

来源：

NATURE REVIEWS IMMUNOLOGY | 2009年 / 9卷 / 12期

关键词：

INDUCED CELL-DEATH; NF-KAPPA-B; LYSOSOMAL CYSTEINE PROTEASES; TUMOR-NECROSIS-FACTOR; HERPES-SIMPLEX-VIRUS; TOLL-LIKE RECEPTORS; GRANZYME-B; INVARIANT CHAIN; DENDRITIC CELLS; CATHEPSIN-L;

D O I：

10.1038/nri2671

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The cellular endolysosomal compartment is dynamic, complex and incompletely understood. Its organelles and constituents vary between different cell types, but endolysosomal proteases are key components of this compartment in all cells. In immune cells, these proteases function in pathogen recognition and elimination, signal processing and cell homeostasis, and they are regulated by dedicated inhibitors. Pathogens can produce analogous proteases to subvert the host immune response. The balance in activity between a protease and its inhibitor can tune the immune response or cause damage as a result of mislocalized proteolysis. In this Review, we highlight recent developments in this area and emphasize the importance of studying the role of endolysosomal proteases, and their natural inhibitors, in the initiation and regulation of immune responses.

引用

页码：871 / 882

页数：12

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