Development of malignant lymphoma after metal-on-metal hip replacement: a case report and review of the literature

被引：16

作者：

McCarthy, C. L. ^{[1
]}

Uchihara, Y. ^{[1
]}

Vlychou, M. ^{[1
]}

Grammatopoulos, G. ^{[1
]}

Athanasou, N. A. ^{[1
]}

机构：

[1] Univ Oxford, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Nuffield Orthopaed Ctr, Windmill Rd, Oxford OX3 7HE, England

来源：

SKELETAL RADIOLOGY | 2017年 / 46卷 / 06期

关键词：

Lymphoma; Metal on metal; Hip implant; CANCER INCIDENCE; PERIPHERAL-BLOOD; NORDIC COHORTS; HUMAN-CELLS; ARTHROPLASTY; COBALT; BEARINGS; IMPLANTS; DEBRIS; RISK;

D O I：

10.1007/s00256-017-2612-y

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

100224 [整形外科学];

摘要：

A number of previous studies have reported a potential risk of malignancy, particularly hematological malignancy, developing in patients receiving a metal-on-metal (MoM) hip replacement. We report a case of malignant lymphoma that arose in a patient who had an MoM hip arthroplasty complicated by development of a pseudotumour. The tumour was a B cell follicular lymphoma that involved lymph nodes and bone. Metal ions are known to have a genotoxic effect on lymphoid cells. Although epidemiological studies have not established that there is an increased risk of lymphoma associated with MoM implants, only a relatively short time period has elapsed since re-introduction of this type of implant and long-term follow-up of patients with MoM implants is indicated.

引用

页码：831 / 836

页数：6

共 40 条

[31]

Genetic alterations in periprosthetic soft-tissue masses from patients with metal-on-metal hip replacement [J].