Polymer-based packaging platform for hybrid microfluidic systems

被引：36

作者：

Krulevitch, P ^{[1
]}

Bennett, W ^{[1
]}

Hamilton, J ^{[1
]}

Maghribi, M ^{[1
]}

Rose, K ^{[1
]}

机构：

[1] Lawrence Livermore Natl Lab, Ctr Micro Technol, Livermore, CA 94551 USA

来源：

BIOMEDICAL MICRODEVICES | 2002年 / 4卷 / 04期

关键词：

packaging; microfluidic systems; polydimethylsiloxane (PDMS); hybrid integration; polymer molding;

D O I：

10.1023/A:1020958323891

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A polymer-based packaging platform for creating hybrid microfluidic systems is presented. Polydimethylsiloxane (PDMS) is cast into an acrylic mold frame with suspended elements that are removed after curing to form chip cavities, inlet and outlet ports, microchannels, and reservoirs. The packaging approach enables the integration of off-the-shelf components such as pumps and valves with glass microfluidic devices, electronic chips, sample reservoirs, and flow channels. A particle pre-concentration module with a glass capture chip and integrated micropump is shown as an example. A pneumatically driven microfluidic pumping module is also shown. Custom microfluidic interconnects for interfacing to micro-scale fluidic systems are presented. The connectors are capable of withstanding more than 1000 psi and allow microdevices to be rapidly connected to macroscopic devices and systems, without the use of tools.

引用

页码：301 / 308

页数：8

共 20 条

[11] Modular concept for fluid handling systems - A demonstrator micro analysis system [J].

Lammerink, TSJ ;

Spiering, VL ;

Elwenspoek, M ;

Fluitman, JHJ ;

vandenBerg, A .

NINTH ANNUAL INTERNATIONAL WORKSHOP ON MICRO ELECTRO MECHANICAL SYSTEMS, IEEE PROCEEDINGS: AN INVESTIGATION OF MICRO STRUCTURES, SENSORS, ACTUATORS, MACHINES AND SYSTEMS, 1996, :389-394

[12]

MAGHRIBI M, 2002, 2 ANN INT IEEE EMBS

[13]

MAGHRIBI MN, 2001, MICRO TOTAL ANAL SYS, P165

[14]

MENSINGER H, 1995, MESA MG, P237

[15]

POPLAWSKI ME, 1994, SOLID STAT SENS ACT, P25

[16] From micro- to nanofabrication with soft materials [J].

Quake, SR ;

Scherer, A .

SCIENCE, 2000, 290 (5496) :1536-1540

[17]

SCHOMBURG WK, 1995, MESA MG, P255

[18] 3-DIMENSIONAL MICRO-FLOW MANIFOLDS FOR MINIATURIZED CHEMICAL-ANALYSIS SYSTEMS [J].

VERPOORTE, EMJ ;

VANDERSCHOOT, BH ;

JEANNERET, S ;

MANZ, A ;

WIDMER, HM ;

DEROOIJ, NF .

JOURNAL OF MICROMECHANICS AND MICROENGINEERING, 1994, 4 (04) :246-256

[19]

VISURI SR, 2001, SPIE, V4560

[20]

Zdeblick M. J., 1994, SOL STAT SENS ACT WO, P251

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