Building drug delivery into tissue engineering

被引：235

作者：

Saltzman, WM ^{[1
]}

Olbricht, WL ^{[1
]}

机构：

[1] Cornell Univ, Sch Chem Engn, Ithaca, NY 14853 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2002年 / 1卷 / 03期

关键词：

D O I：

10.1038/nrd744

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The creation of efficient methods for manufacturing biotechnology drugs - many of which influence fundamental but complex cell behaviours, such as proliferation, migration and differentiation - is creating new opportunities for tissue repair. Many agents are potent and multifunctional; that is, they produce different effects within different tissues. Therefore, control of tissue concentration and spatial localization of delivery is essential for safety and effectiveness. Synthetic systems that can control agent delivery are particularly promising as materials for enhancing tissue regeneration. This review discusses the state of the art in controlled-release and microfluidic drug delivery technologies, and outlines their potential applications for tissue engineering.

引用

页码：177 / 186

页数：10

共 93 条

[1]

Baldwin SP, 1996, TRENDS POLYM SCI, V4, P177

[2] CONTROLLED GROWTH-FACTOR DELIVERY INDUCES DIFFERENTIAL NEURITE OUTGROWTH IN 3-DIMENSIONAL CELL-CULTURES [J].