Noncoding RNAs and gene silencing

被引：342

作者：

Zaratiegui, Mikel ^{[1
]}

Irvine, Danielle V. ^{[1
]}

Martienssen, Robert A. ^{[1
]}

机构：

[1] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA

来源：

CELL | 2007年 / 128卷 / 04期

关键词：

D O I：

10.1016/j.cell.2007.02.016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Noncoding RNA has long been proposed to control gene expression via sequence-specific interactions with regulatory regions. Here, we review the role of noncoding RNA in heterochromatic silencing and in the silencing of transposable elements (TEs), unpaired DNA in meiosis, and developmentally excised DNA. The role of cotranscriptional processing by RNA interference and by other mechanisms is discussed, as well as parallels with RNA silencing in imprinting, paramutation, polycomb silencing, and X inactivation. Interactions with regulatory sequences may well occur, but at the RNA rather than at the DNA level. © 2007 Elsevier Inc. All rights reserved.

引用

页码：763 / 776

页数：14

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