Soluble polymer-supported synthesis of imines and β-lactams

被引:41
作者
Molteni, V
Annunziata, R
Cinquini, M
Cozzi, F
Benaglia, M
机构
[1] Univ Milan, Ctr CNR, I-20133 Milan, Italy
[2] Univ Milan, Dipartimento Chim Organ & Ind, I-20133 Milan, Italy
关键词
D O I
10.1016/S0040-4039(97)10770-5
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The first synthesis of beta-lactams bound to a soluble/insoluble polyethylene glycol monomethylether polymeric matrix has been realized by standard reactions carried out on immobilized imines. beta-Lactams removal from the polymer has been accomplished under acidic and basic conditions. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:1257 / 1260
页数:4
相关论文
共 23 条
[11]   Organic synthesis on soluble polymer supports: Liquid-phase methodologies [J].
Gravert, DJ ;
Janda, KD .
CHEMICAL REVIEWS, 1997, 97 (02) :489-509
[12]   Azatides: Solution and liquid phase syntheses of a new peptidomimetic [J].
Han, H ;
Janda, KD .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (11) :2539-2544
[13]  
HAN H, 1996, LJ AM CHEM SOC, V118, P7632
[14]   A soluble polymer-bound approach to the sharpless catalytic asymmetric dihydroxylation (AD) reaction: Preparation and application of a [(DHQD)(2)PHAL-PEG-OMe] ligand [J].
Han, HS ;
Janda, KD .
TETRAHEDRON LETTERS, 1997, 38 (09) :1527-1530
[15]   LIQUID-PHASE COMBINATORIAL SYNTHESIS [J].
HAN, HS ;
WOLFE, MM ;
BRENNER, S ;
JANDA, KD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (14) :6419-6423
[16]   THE ESTER ENOLATE IMINE CONDENSATION ROUTE TO BETA-LACTAMS [J].
HART, DJ ;
HA, DC .
CHEMICAL REVIEWS, 1989, 89 (07) :1447-1465
[17]   Solid-phase organic reactions: A review of the recent literature [J].
Hermkens, PHH ;
Ottenheijm, HCJ ;
Rees, D .
TETRAHEDRON, 1996, 52 (13) :4527-4554
[18]  
JANDA KD, 1996, Patent No. 03418
[19]   A linker that allows efficient formation of aliphatic C-H bonds on polymeric supports [J].
Jung, KW ;
Zhao, XY ;
Janda, KD .
TETRAHEDRON LETTERS, 1996, 37 (36) :6491-6494
[20]  
LOWE G, 1995, CHEM SOC REV, P309