Cembranoids from the Soft Corals Sinularia granosa and Sinularia querciformis

被引：29

作者：

Lu, Yi ^{[1
]}

Su, Jui-Hsin ^{[3
]}

Huang, Chiung-Yao ^{[1
]}

Liu, Yung-Chun ^{[3
]}

Kuo, Yao-Haur ^{[4
]}

Wen, Zhi-Hong ^{[1
]}

Hsu, Chi-Hsin ^{[1
]}

Sheu, Jyh-Horng ^{[1
,2
]}

机构：

[1] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

[2] Natl Sun Yat Sen Univ, Asia Pacific Ocean Res Ctr, Kaohsiung 804, Taiwan

[3] Meiho Inst Technol, Dept Biol Sci & Technol, Neipu Hsiang 912, Pingtung, Taiwan

[4] Natl Res Inst Chinese Med, Taipei 112, Taiwan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2010年 / 58卷 / 04期

关键词：

cembranoid; soft coral; anti-inflammatory activity; Sinularia granosa; TUMOR-CELL-LINES; OXYGENATED CEMBRANOIDS; DITERPENOIDS; FLEXIBILIS; ASSAY;

D O I：

10.1248/cpb.58.464

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new cembranoids, namely granosolides C (1) and D (2), along with one known cembranoid 4, were isolated from the soft coral Sinularia granosa. Chemical investigation of Sinularia querciformis also afforded one new cembranoid, querciformolide E (3), along with four known cembranoids 4-7. The structures of these compounds were elucidated on the basis of their spectroscopic data. Both 4 and 5 were shown to significantly inhibit the accumulation of the pro-inflammatory inducible nitric oxide synthase protein in lipopolysaccharide-stimulated RAW264.7 macrophage cells.

引用

页码：464 / 466

页数：3

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