Cembranoids from the Soft Corals Sinularia granosa and Sinularia querciformis

被引：29

作者：

Lu, Yi ^{[1
]}

Su, Jui-Hsin ^{[3
]}

Huang, Chiung-Yao ^{[1
]}

Liu, Yung-Chun ^{[3
]}

Kuo, Yao-Haur ^{[4
]}

Wen, Zhi-Hong ^{[1
]}

Hsu, Chi-Hsin ^{[1
]}

Sheu, Jyh-Horng ^{[1
,2
]}

机构：

[1] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

[2] Natl Sun Yat Sen Univ, Asia Pacific Ocean Res Ctr, Kaohsiung 804, Taiwan

[3] Meiho Inst Technol, Dept Biol Sci & Technol, Neipu Hsiang 912, Pingtung, Taiwan

[4] Natl Res Inst Chinese Med, Taipei 112, Taiwan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2010年 / 58卷 / 04期

关键词：

cembranoid; soft coral; anti-inflammatory activity; Sinularia granosa; TUMOR-CELL-LINES; OXYGENATED CEMBRANOIDS; DITERPENOIDS; FLEXIBILIS; ASSAY;

D O I：

10.1248/cpb.58.464

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new cembranoids, namely granosolides C (1) and D (2), along with one known cembranoid 4, were isolated from the soft coral Sinularia granosa. Chemical investigation of Sinularia querciformis also afforded one new cembranoid, querciformolide E (3), along with four known cembranoids 4-7. The structures of these compounds were elucidated on the basis of their spectroscopic data. Both 4 and 5 were shown to significantly inhibit the accumulation of the pro-inflammatory inducible nitric oxide synthase protein in lipopolysaccharide-stimulated RAW264.7 macrophage cells.

引用

页码：464 / 466

页数：3

共 15 条

[11]

SCUDIERO DA, 1988, CANCER RES, V48, P4827

[12] Manaarenolides A-I, diterpenoids from the soft coral Sinularia manaarensis [J].

Su, Jui-Hsin ;

Ahmed, Atallah F. ;

Sung, Ping-Jyun ;

Chao, Chih-Hua ;

Kuo, Yao-Haur ;

Sheu, Jyh-Horng .

JOURNAL OF NATURAL PRODUCTS, 2006, 69 (08) :1134-1139

[13] Oxygenated Cembranoids from the Cultured and Wild-Type Soft Corals Sinularia flexibilis [J].

Su, Jui-Hsin ;

Lin, Yu-Fang ;

Lu, Yi ;

Yeh, Hsiao-Chien ;

Wang, Wei-Hsien ;

Fan, Tung-Yung ;

Sheu, Jyh-Horng .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2009, 57 (11) :1189-1192

[14] Sinulochmodins A-C, three novel terpenoids from the soft coral Sinularia lochmodes [J].

Tseng, YJ ;

Ahmed, AF ;

Dai, CF ;

Chiang, MY ;

Sheu, JH .

ORGANIC LETTERS, 2005, 7 (17) :3813-3816

[15] Sinulaflexiolides A-K, cembrane-type diterpenoids from the Chinese soft coral Sinularia flexibilis [J].

Wen, Ting ;

Ding, Yi ;

Deng, Zhiwei ;

van Ofwegen, Leen P. ;

Proksch, Peter ;

Lin, Wenhan .

JOURNAL OF NATURAL PRODUCTS, 2008, 71 (07) :1133-1140

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