Mechanisms of inflammation in gout

被引：224

作者：

Busso, Nathalie ^{[1
]}

So, Alexander ^{[1
]}

机构：

[1] Univ Lausanne, CHU Vaudois, Serv Rheumatol, CH-1011 Lausanne, Switzerland

来源：

ARTHRITIS RESEARCH & THERAPY | 2010年 / 12卷 / 02期

关键词：

MONOSODIUM URATE CRYSTALS; NECROSIS-FACTOR-ALPHA; AIR POUCH MODEL; NALP3; INFLAMMASOME; NEUTROPHIL RECRUITMENT; MONOHYDRATE CRYSTALS; SYNOVIAL-FLUID; MAST-CELLS; ACTIVATION; COMPLEMENT;

D O I：

10.1186/ar2952

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

An acute attack of gout is a paradigm of acute sterile inflammation, as opposed to pyogenic inflammation. Recent studies suggest that the triggering of IL-1 beta release from leucocytes lies at the heart of a cascade of processes that involves multiple cytokines and mediators. The NLRP3 inflammasome appears to have a specific role in this regard, but the biochemical events leading to its activation are still not well understood. We review the known mechanisms that underlie the inflammatory process triggered by urate crystals and suggest areas that require further research.

引用

页数：8

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