Chiral macrocycle-catalyzed highly enantioselective phenylacetylene addition to aliphatic and vinyl aldehydes

被引：50

作者：

Li, Zi-Bo ^{[1
]}

Liu, Tian-Dong ^{[1
]}

Pu, Lin ^{[1
]}

机构：

[1] Univ Virginia, Dept Chem, Charlottesville, VA 22904 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 72卷 / 12期

关键词：

D O I：

10.1021/jo070091j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The 1,1'-binaphthyl macrocycle (S)-2 is found to be an excellent catalyst for the alkyne addition to aldehydes. In the presence of (S)-2 (20 mol %) and Me2Zn (2 equiv) in THF at room temperature, the addition of phenylacetylene to linear or branched aliphatic aldehydes and vinyl aldehydes gave various propargylic alcohols with 89-96% ee.

引用

页码：4340 / 4343

页数：4

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