The value-added genome: building and maintaining genomic cytosine methylation landscapes

被引：53

作者：

Rangwala, SH ^{[1
]}

Richards, EJ ^{[1
]}

机构：

[1] Washington Univ, Dept Biol, St Louis, MO 63108 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2004年 / 14卷 / 06期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/j.gde.2004.09.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Epigenetic marks, such as cytosine methylation and post-translational histone modifications, are important for interpreting and managing eukaryotic genomes. Recent genetic studies in plants have uncovered details on the different interwoven mechanisms that are responsible for specification of genomic cytosine methylation patterns. These mechanisms include targeting cytosine methylation using heterochromatic histone modifications and RNA guides. Genomic cytosine methylation patterns also reflect locus-specific demethylation initiated by specialized DNA glycosylases. While genetics continues to more fully define these mechanisms, genomic studies in Arabidopsis have yielded an unprecedented high-resolution view of how epigenetic marks are layered over a genome.

引用

收藏

页码：686 / 691

页数：6

相关论文

共 56 条

[31] Endogenous and silencing-associated small RNAs in plants [J].

Llave, C ;

Kasschau, KD ;

Rector, MA ;

Carrington, JC .

PLANT CELL, 2002, 14 (07) :1605-1619

[32] An Arabidopsis SET domain protein required for maintenance but not establishment of DNA methylation [J].

Malagnac, F ;

Bartee, L ;

Bender, J .

EMBO JOURNAL, 2002, 21 (24) :6842-6852

[33] Changes in 5S rDNA chromatin organization and transcription during heterochromatin establishment in Arabidopsis [J].

Mathieu, O ;

Jasencakova, Z ;

Vaillant, I ;

Gendrel, AV ;

Colot, V ;

Schubert, I ;

Tourmente, S .

PLANT CELL, 2003, 15 (12) :2929-2939

[34] Genetic analysis of RNA-mediated transcriptional gene silencing [J].

Matzke, M ;

Aufsatz, W ;

Kanno, T ;

Daxinger, L ;

Papp, I ;

Mette, AF ;

Matzke, AJM .

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 2004, 1677 (1-3) :129-141

[35]

McCombie WR, 2000, CELL, V100, P377, DOI 10.1016/S0092-8674(00)80673-X

[36] Transcription from an upstream promoter controls methylation signaling from an inverted repeat of endogenous genes in Arabidopsis [J].

Melquist, S ;

Bender, J .

GENES & DEVELOPMENT, 2003, 17 (16) :2036-2047

[37] Mobilization of transposons by a mutation abolishing full DNA methylation in Arabidopsis [J].

Miura, A ;

Yonebayashi, S ;

Watanabe, K ;

Toyama, T ;

Shimada, H ;

Kakutani, T .

NATURE, 2001, 411 (6834) :212-214

[38] Maize genome sequencing by methylation filtrations [J].

Palmer, LE ;

Rabinowicz, PD ;

O'Shaughnessy, AL ;

Balija, VS ;

Nascimento, LU ;

Dike, S ;

de la Bastide, M ;

Martienssen, RA ;

McCombie, WR .

SCIENCE, 2003, 302 (5653) :2115-2117

[39] Arabidopsis histone deacetylase HDA6 is required for maintenance of transcriptional gene silencing and determines nuclear organization of rDNA repeats [J].

Probst, AV ;

Fagard, M ;

Proux, F ;

Mourrain, P ;

Boutet, S ;

Earley, K ;

Lawrence, RJ ;

Pikaard, CS ;

Murfett, J ;

Furner, I ;

Vaucheret, H ;

Scheid, OM .

PLANT CELL, 2004, 16 (04) :1021-1034

[40] Genes and transposons are differentially methylated in plants, but not in mammals [J].

Rabinowicz, PD ;

Palmer, LE ;

May, BP ;

Hemann, MT ;

Lowe, SW ;

McCombie, WR ;

Martienssen, RA .

GENOME RESEARCH, 2003, 13 (12) :2658-2664

← 1 2 3 4 5 6 →