Mitochondrial sirtuins

被引：197

作者：

Huang, Jing-Yi ^{[1
]}

Hirschey, Matthew D. ^{[1
]}

Shimazu, Tadahiro ^{[1
]}

Ho, Linh ^{[1
]}

Verdin, Eric ^{[1
]}

机构：

[1] Univ Calif San Francisco, Gladstone Inst Virol & Immunol, San Francisco, CA 94158 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS | 2010年 / 1804卷 / 08期

关键词：

Mitochondria; Sirtuin; SIRT3; SIRT4; SIRT5; O-Acetyl-ADP-ribose; Acetylation; ACETYL-ADP-RIBOSE; INSULIN DEGRADING ENZYME; COLONY-ENHANCING FACTOR; RAT-LIVER MITOCHONDRIA; COA SYNTHETASE 2; YEAST SIR2 GENE; GLUTAMATE-DEHYDROGENASE; CALORIE RESTRICTION; LYSINE ACETYLATION; DEPENDENT DEACETYLASE;

D O I：

10.1016/j.bbapap.2009.12.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sirtuins have emerged as important proteins in aging, stress resistance and metabolic regulation. Three sirtuins, SIRT3, 4 and 5, are located within the mitochondrial matrix. SIRT3 and SIRT5 are NAD(+)-dependent deacetylases that remove acetyl groups from acetyllysine-modified proteins and yield 2'-O-acetyl-ADP-ribose and nicotinamide. SIRT4 can transfer the ADP-ribose group from NAD(+) onto acceptor proteins. Recent findings reveal that a large fraction of mitochondrial proteins are acetylated and that mitochondrial protein acetylation is modulated by nutritional status. This and the identification of targets for SIRT3, 4 and 5 support the model that mitochondrial sirtuins are metabolic sensors that modulate the activity of metabolic enzymes via protein deacetylation or mono-ADP-ribosylation. Here, we review and discuss recent progress in the study of mitochondrial sirtuins and their targets. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：1645 / 1651

页数：7

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