Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-α/β gene induction

被引：1141

作者：

Sato, M

Suemori, H

Hata, N

Asagiri, M

Ogasawara, K

Nakao, K

Nakaya, T

Katsuki, M

Noguchi, S

Tanaka, N

Taniguchi, T

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Immunol, Bunkyo Ku, Tokyo 1130033, Japan

[2] Univ Tokyo, Fac Med, Bunkyo Ku, Tokyo 1130033, Japan

[3] Kanagawa Acad Sci & Technol, Bio Signal Pathway Project, Odawara, Kanagawa 2500862, Japan

[4] Meiji Milk Prod Co Ltd, Odawara, Kanagawa 2500862, Japan

[5] Univ Tokyo, Inst Med Sci, Dept DNA Biol & Embryo Engn, Minato Ku, Tokyo 1068639, Japan

来源：

IMMUNITY | 2000年 / 13卷 / 04期

关键词：

D O I：

10.1016/S1074-7613(00)00053-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Induction of the interferon (IFN)-alpha/beta gene transcription in virus-infected cells is an event central to innate immunity. Mice lacking the transcription factor IRF-3 are more vulnerable to virus infection. In embryonic fibroblasts, virus-induced IFN-alpha/beta gene expression levels are reduced and the spectrum of the IFN-alpha mRNA subspecies altered. Furthermore, cells additionally defective in IRF-7 expression totally fail to induce these genes in response to infections by any of the virus types tested. In these cells, a normal profile of IFN-alpha/beta mRNA induction can be achieved by coexpressing both IRF-3 and IRF-7. These results demonstrate the essential and distinct roles of the two factors, which together ensure the transcriptional efficiency and diversity of IFN-alpha/beta genes for the antiviral response.

引用

页码：539 / 548

页数：10

共 54 条

[21] POSSIBLE INVOLVEMENT OF THE TRANSCRIPTION FACTOR ISGF3-GAMMA IN VIRUS-INDUCED EXPRESSION OF THE IFN-BETA GENE
KAWAKAMI, T
MATSUMOTO, M
SATO, M
HARADA, H
TANIGUCHI, T
KITAGAWA, M
[J]. FEBS LETTERS, 1995, 358 (03) : 225 - 229
[22] Essential and non-redundant roses of p48 (ISGF3 gamma) and IRF-1 in both type I and type II interferon responses, as revealed by gene targeting studies
Kimura, T
Kadokawa, Y
Harada, H
Matsumoto, M
Sato, M
Kashiwazaki, Y
Tarutani, M
Tan, RSP
Takasugi, T
Matsuyama, T
Mak, TW
Noguchi, S
Taniguchi, T
[J]. GENES TO CELLS, 1996, 1 (01) : 115 - 124
[23] SYNERGISM BETWEEN DISTINCT ENHANSON DOMAINS IN VIRAL INDUCTION OF THE HUMAN BETA-INTERFERON GENE
LEBLANC, JF
COHEN, L
RODRIGUES, M
HISCOTT, J
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (08) : 3987 - 3993
[24] THE INVOLVEMENT OF NF-KAPPAB IN BETA-INTERFERON GENE-REGULATION REVEALS ITS ROLE AS WIDELY INDUCIBLE MEDIATOR OF SIGNAL TRANSDUCTION
LENARDO, MJ
FAN, CM
MANIATIS, T
BALTIMORE, D
[J]. CELL, 1989, 57 (02) : 287 - 294
[25] Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation
Lin, RT
Heylbroeck, C
Pitha, PM
Hiscott, J
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (05) : 2986 - 2996
[26] Interferon regulatory factors:: the next generation
Mamane, Y
Heylbroeck, C
Génin, P
Algarté, M
Servant, MJ
LePage, C
DeLuca, C
Kwon, H
Lin, RT
Hiscott, J
[J]. GENE, 1999, 237 (01) : 1 - 14
[27] MANIATIS T, 1992, TRANSCRIPTIONAL REGU, V2, P1193
[28] Differential viral induction of distinct interferon-α genes by positive feedback through interferon regulatory factor-7
Marié, I
Durbin, JE
Levy, DE
[J]. EMBO JOURNAL, 1998, 17 (22) : 6660 - 6669
[29] MATSUYAMA T, 1993, CELL, V75, P83, DOI 10.1016/S0092-8674(05)80086-8
[30] REGULATED EXPRESSION OF A GENE ENCODING A NUCLEAR FACTOR, IRF-1, THAT SPECIFICALLY BINDS TO IFN-BETA-GENE REGULATORY ELEMENTS
MIYAMOTO, M
FUJITA, T
KIMURA, Y
MARUYAMA, M
HARADA, H
SUDO, Y
MIYATA, T
TANIGUCHI, T
[J]. CELL, 1988, 54 (06) : 903 - 913

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