Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-α/β gene induction

被引：1141

作者：

Sato, M

Suemori, H

Hata, N

Asagiri, M

Ogasawara, K

Nakao, K

Nakaya, T

Katsuki, M

Noguchi, S

Tanaka, N

Taniguchi, T

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Immunol, Bunkyo Ku, Tokyo 1130033, Japan

[2] Univ Tokyo, Fac Med, Bunkyo Ku, Tokyo 1130033, Japan

[3] Kanagawa Acad Sci & Technol, Bio Signal Pathway Project, Odawara, Kanagawa 2500862, Japan

[4] Meiji Milk Prod Co Ltd, Odawara, Kanagawa 2500862, Japan

[5] Univ Tokyo, Inst Med Sci, Dept DNA Biol & Embryo Engn, Minato Ku, Tokyo 1068639, Japan

来源：

IMMUNITY | 2000年 / 13卷 / 04期

关键词：

D O I：

10.1016/S1074-7613(00)00053-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Induction of the interferon (IFN)-alpha/beta gene transcription in virus-infected cells is an event central to innate immunity. Mice lacking the transcription factor IRF-3 are more vulnerable to virus infection. In embryonic fibroblasts, virus-induced IFN-alpha/beta gene expression levels are reduced and the spectrum of the IFN-alpha mRNA subspecies altered. Furthermore, cells additionally defective in IRF-7 expression totally fail to induce these genes in response to infections by any of the virus types tested. In these cells, a normal profile of IFN-alpha/beta mRNA induction can be achieved by coexpressing both IRF-3 and IRF-7. These results demonstrate the essential and distinct roles of the two factors, which together ensure the transcriptional efficiency and diversity of IFN-alpha/beta genes for the antiviral response.

引用

页码：539 / 548

页数：10

共 54 条

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