A low hydraulic capacitance pressure sensor for integration with a micro viscosity detector

被引:9
作者
van der Heyden, FHJ
Blom, MT
Gardeniers, JGE
Chmela, E
Elwenspoek, M
Tijssen, R
van den Berg, A
机构
[1] Univ Twente, MESA Res Inst, NL-7500 AE Enschede, Netherlands
[2] Univ Amsterdam, Dept Chem Engn, NL-1018 WV Amsterdam, Netherlands
关键词
low hydraulic capacitance pressure sensor; integrated differential viscosity detection; optical sensing; polymer analysis;
D O I
10.1016/S0925-4005(03)00099-6
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
A design is presented for a micromachined differential viscometer, that is suitable for integration into a planar hydrodynamic chromatography system (HDC) for polymer analysis. The viscometer consists of four equal flow restrictions and two pressure sensors, connected in a Wheatstone bridge configuration. Since this viscometer requires an ultra-low hydraulic capacitance differential pressure sensor, a pressure sensor is presented of which the internal volume displacement was reduced considerably compared to commercially available sensors. An optical method was used to detect membrane deflections with a magnitude of approximately 0.01 nm. This method lead to a linearity of 1% over the measured pressure range and a resolution of 2 Pa. With this pressure sensor integrated into the viscosity detector, viscosity measurements were performed on the viscosity difference of ethanol and water. (C) 2003 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:102 / 109
页数:8
相关论文
共 16 条
[1]  
Barnes H.A., 1989, INTRO RHEOLOGY, V1st, P16
[2]   Design and fabrication of a hydrodynamic chromatography chip [J].
Blom, MT ;
Chmela, E ;
Gardeniers, JGE ;
Tijssen, R ;
Elwenspoek, M ;
van den Berg, A .
SENSORS AND ACTUATORS B-CHEMICAL, 2002, 82 (01) :111-116
[3]   Electroosmosis- and pressure-driven chromatography in chips using continuous beds [J].
Ericson, C ;
Holm, J ;
Ericson, T ;
Hjertén, S .
ANALYTICAL CHEMISTRY, 2000, 72 (01) :81-87
[4]   THE DIFFERENTIAL VISCOMETER .1. A NEW APPROACH TO THE MEASUREMENT OF SPECIFIC VISCOSITIES OF POLYMER-SOLUTIONS [J].
HANEY, MA .
JOURNAL OF APPLIED POLYMER SCIENCE, 1985, 30 (07) :3023-3036
[6]   Capillary electrochromatography of peptides in a microfabricated system [J].
He, B ;
Ji, JY ;
Regnier, FE .
JOURNAL OF CHROMATOGRAPHY A, 1999, 853 (1-2) :257-262
[7]   Fabrication of nanocolumns for liquid chromatography [J].
He, B ;
Tait, N ;
Regnier, F .
ANALYTICAL CHEMISTRY, 1998, 70 (18) :3790-3797
[8]   Liquid chromatography on-chip:: progression towards a μ-total analysis system [J].
McEnery, M ;
Tan, AM ;
Alderman, J ;
Patterson, J ;
O'Mathuna, SC ;
Glennon, JD .
ANALYST, 2000, 125 (01) :25-27
[9]   Comparison of on-line single-capillary and bridge capillary viscometric detectors for size exclusion chromatography [J].
Norwood, DP ;
Reed, WF .
INTERNATIONAL JOURNAL OF POLYMER ANALYSIS AND CHARACTERIZATION, 1997, 4 (02) :99-132
[10]  
OCVIRK G, 1995, ANAL METHOD INSTRUM, V2, P74