Combinatorial approach to the asymmetric hydrogenation of β-acylamino acrylates:: use of mixtures of chiral monodentate P-ligands

被引：59

作者：

Reetz, MT ^{[1
]}

Li, XG ^{[1
]}

机构：

[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany

来源：

TETRAHEDRON | 2004年 / 60卷 / 43期

关键词：

phosphonite; phosphite; beta-acylamino acrylate;

D O I：

10.1016/j.tet.2004.07.042

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The previously proposed concept of using mixtures of two different chiral monodentate P-ligands has been extended to the asymmetric Rh-catalyzed hydrogenation of beta-acylamino acrylates with formation of chiral beta-amino acid derivatives. Mixtures of BINOL-derived phosphites and phosphonites are particularly effective (ee=94-99% for five different substrates). (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：9709 / 9714

页数：6

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