Regioselective Synthesis of tert-Allylic Ethers via Gold(I)-Catalyzed Intermolecular Hydroalkoxylation of Allenes

被引：61

作者：

Hadfield, Maximillian S. ^{[1
]}

Lee, Ai-Lan ^{[1
]}

机构：

[1] Heriot Watt Univ, Sch Engn & Phys Sci, Edinburgh EH14 4AS, Midlothian, Scotland

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 03期

基金：

英国工程与自然科学研究理事会;

关键词：

GOLD-CATALYZED CYCLOISOMERIZATION; DERIVATIVES; CYCLIZATION; EFFICIENT; ALCOHOL; HYDROXYALLENES; OPPORTUNITIES; HETEROCYCLES; CARBOCYCLES; REDUCTION;

D O I：

10.1021/ol902675k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly regloselective method towards tertiary allylic ethers via gold(I)-catalyzed intermolecular hydroalkoxylation of allenes is disclosed. Preventing subsequent Isomerization of the tertiary allylic ether products to primary allylic ethers appears to be the key to achieving high regioselectivities.

引用

页码：484 / 487

页数：4

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