New briarane stecholide diterpenes from the Indonesian gorgonian Briareum sp.

被引：36

作者：

Rodríguez, J ^{[1
]}

Nieto, RM ^{[1
]}

Jiménez, C ^{[1
]}

机构：

[1] Univ A Coruna, Fac Ciencias, Dept Quim Fundamental & Ind, La Coruna 15071, Spain

来源：

JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 03期

关键词：

D O I：

10.1021/np9703510

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The Indonesian gorgonian Briareum sp. has afforded two new briarane stecholide diterpenes: 2,9-diacetyl-2-debutyrylstecholide H (1) and 13-dehydroxystecholide J (2), the semisynthetic 2 beta-acetoxy-2-(debutyryloxy)stecholide E acetate (3), which was isolated as a natural product for the first time, along with the known compounds stecholides I-M (4-8), stecholide A acetate (9), and stecholide C acetate (10). The structures of the new compounds were deduced by extensive NMR studies (H-1, C-13, H-1-H-1 COSY, NOESY, HMQC, and HMBC) and FABMS data (HR and LR). Cytotoxic activity was found for the first time in stecholide L (7).

引用

页码：313 / 317

页数：5

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