Air-Stable Secondary Phosphine Oxide or Chloride (Pre)Ligands for Cross-Couplings of Unactivated Alkyl Chlorides

被引：59

作者：

Ackermann, Lutz ^{[1
]}

Kapdi, Anant R. ^{[1
]}

Schulzke, Carola ^{[2
]}

机构：

[1] Univ Gottingen, Inst Organ & Biomol Chem, D-37077 Gottingen, Germany

[2] Univ Gottingen, Inst Anorgan Chem, D-37077 Gottingen, Germany

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 10期

关键词：

POSSESSING BETA-HYDROGENS; ARYL GRIGNARD-REAGENTS; DIRECT ARYLATIONS; C-C; HALIDES; CATALYSTS; PRELIGANDS; NICKEL; LIGANDS; ACID;

D O I：

10.1021/ol100658y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In situ generated and crystallographically well-defined, isolated palladium complexes derived from seven novel air-stable secondary phosphine oxides or chlorides enabled challenging Kumada-Corriu cross-couplings of unactivated alkyl chlorides bearing beta-hydrogens and proved applicable to transformations of alkyl-substituted organometallics.

引用

页码：2298 / 2301

页数：4

共 60 条

[1] Air-stable phosphine oxides as preligands for catalytic activation reactions of C-Cl, C-F, and C-H bonds
Ackermann, L
Born, R
Spatz, JH
Althammer, A
Gschrei, CJ
[J]. PURE AND APPLIED CHEMISTRY, 2006, 78 (02) : 209 - 214
[2] Phosphine oxides as preligands in ruthenium-catalyzed arylations via C-H bond functionalization using aryl chlorides
Ackermann, L
[J]. ORGANIC LETTERS, 2005, 7 (14) : 3123 - 3125
[3] Assisted ruthenium-catalyzed C-H bond activation: Carboxylic acids as cocatalysts for generally applicable direct arylations in apolar solvents
Ackermann, Lutz
Vicente, Ruben
Althammer, Andreas
[J]. ORGANIC LETTERS, 2008, 10 (11) : 2299 - 2302
[4] Ruthenium(IV) alkylidenes as precatalysts for direct arylations of Alkenes with aryl chlorides and an application to sequential catalysis
Ackermann, Lutz
Born, Robert
Alvarez-Bercedo, Paula
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2007, 46 (33) : 6364 - 6367
[5] Catalytic arylations with challenging substrates: From air-stable HASPO preligands to indole syntheses and C-H-bond functionalizations
Ackermann, Lutz
[J]. SYNLETT, 2007, (04) : 507 - 526
[6] Air- and moisture-stable secondary phosphine oxides as preligands in catalysis
Ackermann, Lutz
[J]. SYNTHESIS-STUTTGART, 2006, 10 (10): : 1557 - 1571
[7] Kumada-Corriu Cross-Couplings with 2-Pyridyl Grignard Reagents
Ackermann, Lutz
Potukuchi, Harish K.
Kapdi, Anant R.
Schulzke, Carola
[J]. CHEMISTRY-A EUROPEAN JOURNAL, 2010, 16 (11) : 3300 - 3303
[8] Air-Stable Secondary Phosphine Oxide as Preligand for Palladium-Catalyzed Intramolecular α-Arylations with Chloroarenes
Ackermann, Lutz
Vicente, Ruben
Hofmann, Nora
[J]. ORGANIC LETTERS, 2009, 11 (19) : 4274 - 4276
[9] [Anonymous], MODERN ARYLATION MET
[10] Simple iron-amine catalysts for the cross-coupling of aryl Grignards with alkyl halides bearing β-hydrogens
Bedford, RB
Bruce, DW
Frost, RM
Hird, M
[J]. CHEMICAL COMMUNICATIONS, 2005, (33) : 4161 - 4163

← 1 2 3 4 5 6 →