Chemical constituents of Garcinia fusca:: Structure elucidation of eight new xanthones and their cancer chemopreventive activity

被引:74
作者
Ito, C
Itoigawa, M [1 ]
Takakura, T
Ruangrungsi, N
Enjo, F
Tokuda, H
Nishino, H
Furukawa, H
机构
[1] Tokai Gakuen Univ, Miyoshi, Aichi 4700207, Japan
[2] Meijo Univ, Fac Pharm, Tempaku Ku, Nagoya, Aichi 4688503, Japan
[3] Chulalongkorn Univ, Fac Pharmaceut Sci, Dept Pharmacognosy, Bangkok 10330, Thailand
[4] Kyoto Prefectural Univ Med, Dept Biochem, Kamigyo Ku, Kyoto 6020841, Japan
来源
JOURNAL OF NATURAL PRODUCTS | 2003年 / 66卷 / 02期
关键词
D O I
10.1021/np020290s
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
We describe the isolation and spectrometric structure elucidation of eight new xanthones, fuscaxanthone A (1), B (2), C (3), D (4), E (5), F (6), G (7), and H (8), together with eight known xanthones from the stem bark of Garcinia fusca collected in Thailand. All the new xanthones were shown to have a terpenoid (prenyl and/or geranyl) side chain(s) in their molecules. We also present the results of a primary screening of the inhibitory effects of eight xanthones (9-16) isolated as major components of this plant on 12-O-tetradecanoylphorbol-13-acetate induced Epstein-Barr virus early antigen activation in Raji cells.
引用
收藏
页码:200 / 205
页数:6
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