Rhodium-catalysed asymmetric hydroformylation of unsaturated nitriles

被引：42

作者：

Lambers-Verstappen, MMH ^{[1
]}

de Vries, JG ^{[1
]}

机构：

[1] DSM Res & Patents, Life Sci Adv Synth & Catalysis, NL-6160 MD Geleen, Netherlands

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2003年 / 345卷 / 04期

关键词：

aldehydes; asymmetric catalysis; homogeneous catalysis; hydroformylation; nitriles; P ligands; rhodium;

D O I：

10.1002/adsc.200390053

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Asymmetric hydroformylation of crotononitrile (1) and ally cyanide (2) was probed with the view to develop a synthesis for (R)-4-amino-2-methyl-butan-1-ol. Hydroformylation of 1 under a variety of conditions mainly led to hydrogenated product. Hydroformylation of 2 with Rh/tris(2,4-di-tert-butylphenyl) phosphite gave good selectivity to the formylated nitrile with an n/iso of 77:23. Asymmetric hydroformylation of 2 could be accomplished in 66% ee using Rh/(R,S)-BINAPHOS.

引用

页码：478 / 482

页数：5

共 47 条

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