Single-Walled Carbon Nanotube-Based Chemiresistive Affinity Biosensors for Small Molecules: Ultrasensitive Glucose Detection

被引：143

作者：

Cella, Lakshmi N. ^{[1
,2
]}

Chen, Wilfred ^{[1
,2
]}

Myung, Nosang V. ^{[1
]}

Mulchandani, Ashok ^{[1
,2
]}

机构：

[1] Univ Calif Riverside, Dept Chem & Environm Engn, Riverside, CA 92521 USA

[2] Univ Calif Riverside, Cell Mol & Dev Biol Grad Program, Riverside, CA 92521 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 14期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

FIELD-EFFECT TRANSISTORS; ELECTRICAL DETECTION; FLOW IMMUNOSENSOR; CONCANAVALIN-A; BINDING; PROTEIN; SENSOR; IMMUNOASSAY; MECHANISM; DEVICES;

D O I：

10.1021/ja100503b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report for the first time single-walled carbon nanotube (SWNT)-based chemiresistive affinity sensors for highly sensitive and selective detection of small and/or weakly charged or uncharged molecules using a displacement format. The detection of glucose, a small, weakly charged molecule, by displacement of plant lectin (concavalin A) bound to a polysaccharide (dextran) immobilized on SWNTs with picomolar sensitivity and selectivity over other sugars and human serum proteins is demonstrated as a proof of concept.

引用

页码：5024 / +

页数：5

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