Structures of topostins, DNA topoisomerase I inhibitors of bacterial origin

被引：15

作者：

Nemoto, T

Ojika, M ^{[1
]}

Takahata, Y

Andoh, T

Sakagami, Y

机构：

[1] Nagoya Univ, Grad Sch Bioagr Sci, Chikusa Ku, Nagoya, Aichi 46401, Japan

[2] Soka Univ, Fac Engn, Tokyo 192, Japan

来源：

TETRAHEDRON | 1998年 / 54卷 / 12期

关键词：

D O I：

10.1016/S0040-4020(98)83004-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The structures of topostins, a novel type of mammalian DNA topoisomerase I inhibitors isolated from the bacterium Flexibacter topostinus sp. nov., have remained unknown. Reexamination of the production of topostins resulted in the isolation of original topostins B (B553 (1) and B567 (2)) and new related compounds named topostins D (D640 (3) and D654(4)). Their structures, including the absolute stereochemistry, were determined by spectroscopic analyses and chemical degradations. These substances are lipid-containing amino acids and peptides. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：2683 / 2690

页数：8

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