Enantioselective alkylation of β-keto esters by phase-transfer catalysis using chiral quaternary ammonium salts

被引：137

作者：

Park, EJ ^{[1
]}

Kim, MH ^{[1
]}

Kim, DY ^{[1
]}

机构：

[1] Soonchunhyang Univ, Dept Chem, Chungnam 336600, South Korea

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2004年 / 69卷 / 20期

关键词：

D O I：

10.1021/jo0401772

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Catalytic enantioselective alkylation promoted by a quaternary ammonium salt from cinchonine as a phase transfer catalyst is described. Treatment of cyclo beta-keto esters with alkyl halide under mild reaction conditions afforded the corresponding alpha-alkylated beta-keto esters in moderate to excellent yields with high enantiomeric excesses.

引用

页码：6897 / 6899

页数：3

共 58 条

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