Syntheses of photolabile novobiocin analogues

被引：32

作者：

Shen, G

Yu, XM

Blagg, BSJ

机构：

[1] Univ Kansas, Dept Med Chem, Lawrence, KS 66045 USA

[2] Univ Kansas, Ctr Prot Struct & Funct, Lawrence, KS 66045 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 23期

关键词：

novobiocin; Hsp90; DNA gyrase;

D O I：

10.1016/j.bmcl.2004.09.017

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novobiocin was recently shown to inhibit Hsp90 through a previously unrecognized C-terminal ATP binding site. Although the N-terminal region of Hsp90 has been solved by X-ray crystallography, the C-terminal region has not. In an effort to elucidate the C-terminal binding site of Hsp90, four photolabile analogues of novobiocin were prepared. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：5903 / 5906

页数：4

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