Functionalized gold nanoparticles for drug delivery

被引:385
作者
Han, Gang [1 ]
Ghosh, Partha [1 ]
Rotello, Vincent M. [1 ]
机构
[1] Univ Massachusetts, Dept Chem, Amherst, MA 01003 USA
关键词
delivery; DNA; drug; gene; glutathione; gold; nanoparticles; photochemistry; release;
D O I
10.2217/17435889.2.1.113
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Functionalized gold nanoparticles represent highly attractive and promising candidates in the applications of drug delivery owing to their unique dimensions, tunable functionalities on the surface and controllable drug release. This review illustrates the recent advances in the field of drug delivery using gold nanoparticles as carriers for therapeutic agents.
引用
收藏
页码:113 / 123
页数:11
相关论文
共 40 条
  • [1] Anderson ME, 1998, CHEM-BIOL INTERACT, V112, P1
  • [2] Berg K, 2004, CURR OPIN MOL THER, V6, P279
  • [3] Gene therapy: A tragic setback
    Check, E
    [J]. NATURE, 2002, 420 (6912) : 116 - 118
  • [4] Nanotechnologies for biomolecular detection and medical diagnostics
    Cheng, MMC
    Cuda, G
    Bunimovich, YL
    Gaspari, M
    Heath, JR
    Hill, HD
    Mirkin, CA
    Nijdam, AJ
    Terracciano, R
    Thundat, T
    Ferrari, M
    [J]. CURRENT OPINION IN CHEMICAL BIOLOGY, 2006, 10 (01) : 11 - 19
  • [5] Gold nanoparticles are taken up by human cells but do not cause acute cytotoxicity
    Connor, EE
    Mwamuka, J
    Gole, A
    Murphy, CJ
    Wyatt, MD
    [J]. SMALL, 2005, 1 (03) : 325 - 327
  • [6] Synthesis and grafting of thioctic acid-PEG-folate conjugates onto Au nanoparticles for selective targeting of folate receptor-positive tumor cells
    Dixit, Vivechana
    Van den Bossche, Jeroen
    Sherman, Debra M.
    Thompson, David H.
    Andres, Ronald P.
    [J]. BIOCONJUGATE CHEMISTRY, 2006, 17 (03) : 603 - 609
  • [7] Toxicity of gold nanoparticles functionalized with cationic and anionic side chains
    Goodman, CM
    McCusker, CD
    Yilmaz, T
    Rotello, VM
    [J]. BIOCONJUGATE CHEMISTRY, 2004, 15 (04) : 897 - 900
  • [8] Han G, 2006, CHEM BIOL DRUG DES, V67, P78, DOI 10.1111/j.1747-0285.2005.00324.x
  • [9] Controlled recovery of the transcription of nanoparticle-bound DNA by intracellular concentrations of glutathione
    Han, G
    Chari, NS
    Verma, A
    Hong, R
    Martin, CT
    Rotello, VM
    [J]. BIOCONJUGATE CHEMISTRY, 2005, 16 (06) : 1356 - 1359
  • [10] Light-regulated release of DNA and its delivery to nuclei by means of photolabile gold nanoparticles
    Han, Gang
    You, Chang-Cheng
    Kim, Byoung-Jin
    Turingan, Rosemary S.
    Forbes, Neil S.
    Martin, Craig T.
    Rotello, Vincent M.
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (19) : 3165 - 3169