Molecular steps of cell suicide: An insight into immune senescence

被引：52

作者：

Gupta, S ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Med, Div Basic & Clin Immunol, Cellular & Mol Immunol Lab, Irvine, CA 92697 USA

[2] Univ Calif Irvine, Dept Med, Div Basic & Clin Immunol, Mol Biol Lab, Irvine, CA 92697 USA

来源：

JOURNAL OF CLINICAL IMMUNOLOGY | 2000年 / 20卷 / 04期

关键词：

aging; apoptosis; TNF receptor; fas; fas ligand; mitochondria;

D O I：

10.1023/A:1006653917314

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The cellular and molecular basis of immune senescence is unclear. A number of mechanisms have been proposed. In this issue of the Journal of Clinical Immunology, some of the mechanisms for Various immunologic abnormalities in aging are presented. In this article, various molecular steps of both death receptor and mitochondrial pathways of apoptosis in general are reviewed. In particular, the role of apoptosis in T-cell immune senescence is discussed.

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收藏

页码：229 / 239

页数：11

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