Distinct osteogenic mechanisms of bones of distinct origins

被引:53
作者
Chung, UI
Kawaguchi, H
Takato, T
Nakamura, K
机构
[1] Tokyo Univ Hosp, Div Tissue Engn, Bunkyo Ku, Tokyo 1138655, Japan
[2] Univ Tokyo, Grad Sch Med, Dept Orthoped Surg, Tokyo, Japan
关键词
osteogenesis; endochondral bone formation; intramembranous bone formation; hypertrophic chondrocytes; Indian hedgehog;
D O I
10.1007/s00776-004-0786-3
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
Mammalian bones have three distinct origins (paraxial mesoderm, lateral plate mesoderm, and neural crest) and undergo two different modes of formation (intramembranous and endochondral). Bones derived from the paraxial mesoderm and lateral plate mesoderm mainly form through the endochondral process. During this process, hypertrophic chondrocytes play a vital role in inducing both osteogenesis and angiogenesis. One of the essential osteogenic factors secreted from hypertrophic chondrocytes is Indian hedgehog (Ihh). In contrast, bones derived from the neural crest mainly form through the intramembranous process and do not require Ihh. Thus, depending on their origin, bones have distinct signaling properties, which need to be considered in the research and application of bone biology.
引用
收藏
页码:410 / 414
页数:5
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