Bismuth(III) complexes derived from non-steroidal anti-inflammatory drugs and their activity against Helicobacter pylori

被引：61

作者：

Andrews, Philip C. ^{[1
]}

Ferrero, Richard L. ^{[2
]}

Junk, Peter C. ^{[1
]}

Kumar, Ish ^{[1
]}

Luu, Quynh ^{[1
]}

Nguyen, Kim ^{[1
]}

Taylor, James W. ^{[1
]}

机构：

[1] Monash Univ, Sch Chem, Melbourne, Vic 3800, Australia

[2] Monash Inst Med Res, Ctr Innate Immun & Infect Dis, Melbourne, Vic 3168, Australia

来源：

DALTON TRANSACTIONS | 2010年 / 39卷 / 11期

关键词：

SOLVENT-FREE; INFECTION; CHEMISTRY; ULCER; SUSCEPTIBILITY; CARBOXYLATES; CRYSTAL; AGENTS;

D O I：

10.1039/c000164c

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The formation of bismuth(III) complexes of carboxylates and benzoates derived from the 1 : 3 reaction of BiPh(3) with the common non-steroidal anti-inflammatory drugs ( NSAIDs) ketoprofen, naproxen, ibuprofen, mefenamic acid, diflunisal, 5-chlorosalicylic acid, fenbufen, sulindac, tolfenamic acid and flufenamic acid, has been achieved using both solvent-free and solvent-mediated methods. The thermochemical profiles of the solvent-free reactions were studied using DSC-TGA. All reactions produced the tris-substituted complexes of general formula [BiL(3)](n), with the complexes derived from ketoprofen and sulindac having an additional single bismuth bound H(2)O molecule in the inner coordination sphere. The complexes are stable in air over a period of six months, do not undergo significant decomposition when suspended overnight in water, but decompose in 1 M HCl solution to release the free acid form of the NSAID. All ten complexes show excellent in vitro activity against Helicobacter pylori with MIC values of >= 6.25 mu g mL(-1).

引用

页码：2861 / 2868

页数：8

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