Himeic acid A:: a new ubiquitin-activating enzyme inhibitor isolated from a marine-derived fungus, Aspergillus sp.

被引：80

作者：

Tsukamoto, S ^{[1
]}

Hirota, H

Imachi, M

Fujimuro, M

Onuki, H

Ohta, T

Yokosawa, H

机构：

[1] Kanazawa Univ, Fac Pharmaceut Sci, Kanazawa, Ishikawa 9201192, Japan

[2] RIKEN, GEN, Tsuzurumi Ku, Yokohama, Kanagawa 2300045, Japan

[3] Yokohama City Univ, Grad Sch Integrated Sci, Tsuzurumi Ku, Yokohama, Kanagawa 2300045, Japan

[4] Bruker BioSpin KK, Tsukuba, Ibaraki 3050051, Japan

[5] Hokkaido Univ, Grad Sch Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 01期

关键词：

ubiquitin-activating enzyme inhibitor; marine-derived fungus; Aspergillus sp;

D O I：

10.1016/j.bmcl.2004.10.012

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new ubiquitin-activating enzyme (E1) inhibitor, himeic acid A, was isolated from a culture of marine-derived fungus, Aspergillus sp. The structure was determined by spectroscopic analysis. The formation of an E1-ubiquitin (Ub) intermediate was 65% inhibited by himeic acid A at the concentration of 50 muM, while two new related compounds, himeic acids B and C, showed little inhibitory activity even at 100 muM. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：191 / 194

页数：4

共 16 条

[11] New polyhydroxy sterols:: Proteasome inhibitors from a marine sponge Acanthodendrilla sp. [J].