New polyhydroxy sterols:: Proteasome inhibitors from a marine sponge Acanthodendrilla sp.

被引：43

作者：

Tsukamoto, S ^{[1
]}

Tatsuno, M

van Soest, RWM

Yokosawa, H

Ohta, T

机构：

[1] Kanazawa Univ, Fac Pharmaceut Sci, Kanazawa, Ishikawa 9200934, Japan

[2] Univ Amsterdam, Zool Museum, Inst Systemat & Ecol, NL-1090 GT Amsterdam, Netherlands

[3] Hokkaido Univ, Grad Sch Pharmaceut Sci, Dept Biochem, Sapporo, Hokkaido 0600812, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 2003年 / 66卷 / 09期

关键词：

D O I：

10.1021/np030120v

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Seven new polyhydroxylated sterols, as well as the known agosterols A, C, and D-2 (8-10), were isolated from a marine sponge Acanthodendrilla sp. as proteasome inhibitors. Their structures were elucidated on the basis of their spectral data, and they were characterized as agosterol congeners, which had been initially isolated from a marine sponge Spongia sp. and reported to reverse multidrug resistance in tumor cells. Among them, agosterol C (9) most strongly inhibited chymotrypsin-like activity of the proteasome with an IC50 value of 10 mug/mL.

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页码：1181 / 1185

页数：5

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