Syntheses, spectral properties and photo stabilities of novel water-soluble near-infrared cyanine dyes

被引：76

作者：

Song, FL ^{[1
]}

Peng, XJ ^{[1
]}

Lu, EH ^{[1
]}

Rong, Z ^{[1
]}

Chen, XY ^{[1
]}

Bo, S ^{[1
]}

机构：

[1] Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116012, Peoples R China

来源：

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY | 2004年 / 168卷 / 1-2期

基金：

中国国家自然科学基金;

关键词：

cyanine dyes; near-infrared dyes; photostability; biological assay; fluorescent dyes;

D O I：

10.1016/j.jphotochem.2004.05.012

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

To develop long wavelength cyanine dyes with good water solubility and high photostability for biological application, a series of heptamethine 5-sulfo-3H-indocyanine dyes were synthesized and characterized. The absorption and fluorescence spectra of the dyes in various solvents are presented, the maximum absorption and emission wavelengths ranging from 680 to 830 nm. The photostabilities are influenced by the different substitutes of the dyes: N-benzyl on the nitrogen atom at the 3H-indole ring provides better photostability than N-ethyl, the substitution of chloro group of chlorocyclohexenyl bridge in heptamethine chain with electron-donor group (such as 4-methoxylanilino) could greatly improve the photostability. In addition, the photofading is more rapid in water than in alcohol and the mechanisms are discussed. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：53 / 57

页数：5

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