INCLUSive: a web portal and service registry for microarray and regulatory sequence analysis

被引:32
作者
Coessens, B [1 ]
Thijs, G [1 ]
Aerts, S [1 ]
Marchal, K [1 ]
De Smet, F [1 ]
Engelen, K [1 ]
Glenisson, P [1 ]
Moreau, Y [1 ]
Mathys, J [1 ]
De Moor, B [1 ]
机构
[1] Katholieke Univ Leuven, ESAT SCD, B-3001 Louvain, Belgium
关键词
D O I
10.1093/nar/gkg615
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
INCLUSive is a suite of algorithms and tools for the analysis of gene expression data and the discovery of cis-regulatory sequence elements. The tools allow normalization, filtering and clustering of microarray data, functional scoring of gene clusters, sequence retrieval, and detection of known and unknown regulatory elements using probabilistic sequence models and Gibbs sampling. All tools are available via different web pages and as web services. The web pages are connected and integrated to reflect a methodology and facilitate complex analysis using different tools. The web services can be invoked using standard SOAP messaging. Example clients are available for download to invoke the services from a remote computer or to be integrated with other applications. All services are catalogued and described in a web service registry. The INCLUSive web portal is available for academic purposes at http://www.esat.kuleuven.ac.be/inclusive.
引用
收藏
页码:3468 / 3470
页数:3
相关论文
共 15 条
  • [1] Toucan:: deciphering the cis-regulatory logic of coregulated genes
    Aerts, S
    Thijs, G
    Coessens, B
    Staes, M
    Moreau, Y
    Moor, BD
    [J]. NUCLEIC ACIDS RESEARCH, 2003, 31 (06) : 1753 - 1764
  • [2] Gene Ontology: tool for the unification of biology
    Ashburner, M
    Ball, CA
    Blake, JA
    Botstein, D
    Butler, H
    Cherry, JM
    Davis, AP
    Dolinski, K
    Dwight, SS
    Eppig, JT
    Harris, MA
    Hill, DP
    Issel-Tarver, L
    Kasarskis, A
    Lewis, S
    Matese, JC
    Richardson, JE
    Ringwald, M
    Rubin, GM
    Sherlock, G
    [J]. NATURE GENETICS, 2000, 25 (01) : 25 - 29
  • [3] Ensembl 2002: accommodating comparative genomics
    Clamp, M
    Andrews, D
    Barker, D
    Bevan, P
    Cameron, G
    Chen, Y
    Clark, L
    Cox, T
    Cuff, J
    Curwen, V
    Down, T
    Durbin, R
    Eyras, E
    Gilbert, J
    Hammond, M
    Hubbard, T
    Kasprzyk, A
    Keefe, D
    Lehvaslaiho, H
    Iyer, V
    Melsopp, C
    Mongin, E
    Pettett, R
    Potter, S
    Rust, A
    Schmidt, E
    Searle, S
    Slater, G
    Smith, J
    Spooner, W
    Stabenau, A
    Stalker, J
    Stupka, E
    Ureta-Vidal, A
    Vastrik, I
    Birney, E
    [J]. NUCLEIC ACIDS RESEARCH, 2003, 31 (01) : 38 - 42
  • [4] Adaptive quality-based clustering of gene expression profiles
    De Smet, F
    Mathys, J
    Marchal, K
    Thijs, G
    De Moor, B
    Moreau, Y
    [J]. BIOINFORMATICS, 2002, 18 (05) : 735 - 746
  • [5] MARAN: normalizing micro-array data
    Engelen, K
    Coessens, B
    Marchal, K
    De Moor, B
    [J]. BIOINFORMATICS, 2003, 19 (07) : 893 - 894
  • [6] Glenisson P, 2003, Pac Symp Biocomput, P391
  • [7] PlantCARE, a database of plant cis-acting regulatory elements and a portal to tools for in silico analysis of promoter sequences
    Lescot, M
    Déhais, P
    Thijs, G
    Marchal, K
    Moreau, Y
    Van de Peer, Y
    Rouzé, P
    Rombauts, S
    [J]. NUCLEIC ACIDS RESEARCH, 2002, 30 (01) : 325 - 327
  • [8] Genome-specific higher-order background models to improve motif detection
    Marchal, K
    Thijs, G
    De Keersmaecker, S
    Monsieurs, P
    De Moor, B
    Vanderleyden, J
    [J]. TRENDS IN MICROBIOLOGY, 2003, 11 (02) : 61 - 66
  • [9] Functional bioinformatics of microarray data: From expression to regulation
    Moreau, Y
    De Smet, F
    Thijs, G
    Marchal, K
    De Moor, B
    [J]. PROCEEDINGS OF THE IEEE, 2002, 90 (11) : 1722 - 1743
  • [10] Spellman PT, 2002, GENOME BIOL, V3