Adolescent development of the reward system

被引:374
作者
Galvan, Adriana [1 ]
机构
[1] Univ Calif Los Angeles, Lab Dev Neurosci, Dept Psychol, Brain Res Inst, Los Angeles, CA 90095 USA
来源
FRONTIERS IN HUMAN NEUROSCIENCE | 2010年 / 4卷
关键词
adolescence; brain development; striatum; reward; RISK-TAKING BEHAVIOR; HUMAN-BRAIN; PREFRONTAL CORTEX; NUCLEUS-ACCUMBENS; NEURAL BASIS; DOPAMINE; CHILDREN; RECEPTOR; PERIADOLESCENT; PERIOD;
D O I
10.3389/neuro.09.006.2010
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Adolescence is a developmental period characterized by increased reward-seeking behavior. Investigators have used functional magnetic resonance imaging (fMRI) in conjunction with reward paradigms to test two opposing hypotheses about adolescent developmental changes in the striatum, a region implicated in reward processing. One hypothesis posits that the striatum is relatively hypo-responsive to rewards during adolescence, such that heightened reward-seeking behavior is necessary to achieve the same activation as adults. Another view suggests that during adolescence the striatal reward system is hyper-responsive, which subsequently results in greater reward-seeking. While evidence for both hypotheses has been reported, the field has generally converged on this latter hypothesis based on compelling evidence. In this review, I describe the evidence to support this notion, speculate on the disparate fMRI findings and conclude with future areas of inquiry to this fascinating question.
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页数:9
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