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Cell surface biology mediated by low affinity multivalent protein-glycan interactions

被引：275
作者：
Collins, BE
Paulson, JC
机构：
[1] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA
[2] Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA
来源：
CURRENT OPINION IN CHEMICAL BIOLOGY | 2004年 / 8卷 / 06期
关键词：
D O I：
10.1016/j.cbpa.2004.10.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Glycan-binding proteins mediate diverse aspects of cell biology including pathogen recognition of host cells, cell trafficking, endocytosis and modulation of cell signaling. This is accomplished despite the intrinsic low affinity for their ligands through multivalent interactions that increase effective affinity and adhesive force. Recent successes in the rational design of high-affinity ligands for glycan-binding proteins offer the promise to create well-defined tools for exploring the structure and functions of this class of receptors.
引用
收藏
页码：617 / 625
页数：9
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