A rhodium(I)-catalyzed demethylation-cyclization of o-anisole-substituted ynamides in the synthesis of chiral 2-amido benzofurans

被引：87

作者：

Oppenheimer, Jossian

Johnson, Whitney L.

Tracey, Michael R.

Hsung, Richard P.

Yao, Pei-Yuan

Liu, Renhe

Zhao, Kang

机构：

[1] Univ Wisconsin, Div Pharmaceut Sci, Madison, WI 53705 USA

[2] Univ Wisconsin, Dept Chem, Madison, WI 53705 USA

[3] Tianjin Univ, Coll Pharmaceut & Biotechnol, Tianjin 300072, Peoples R China

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 12期

关键词：

D O I：

10.1021/ol0707362

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Rh(I)-catalyzed demethylation-cyclization sequence for a direct transformation of o-anisole-substituted ynamides to benzofurans is described here. The Ag salt functions synergistically with Rh(I) for the key demethylation step.

引用

页码：2361 / 2364

页数：4

共 61 条

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