Zinc Chloride Promoted Formal Oxidative Coupling of Aromatic Aldehydes and Isocyanides to α-Ketoamides

被引：81

作者：

Bouma, Marinus ^{[1
]}

Masson, Geraldine ^{[1
]}

Zhu, Jieping ^{[1
]}

机构：

[1] CNRS, Ctr Rech Gif, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 75卷 / 08期

关键词：

ONE-POT SYNTHESIS; INTERMOLECULAR STETTER REACTION; UGI 4-COMPONENT CONDENSATION; KETO AMIDE INHIBITORS; DOUBLE CARBONYLATION; EFFICIENT SYNTHESIS; PROTEASE INHIBITOR; PASSERINI REACTION; MULTICOMPONENT REACTION; DIASTEREOSELECTIVE ALLYLATION;

D O I：

10.1021/jo100302y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reaction of aromatic aldehydes and isocyanides in the presence of N-methylhydroxyamine, acetic acid, and zinc chloride affords the aryl alpha-ketoamides in moderate to good yields.

引用

页码：2748 / 2751

页数：4

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